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KMID : 0848120130380040149
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International Journal of Oral Biology
2013 Volume.38 No. 4 p.149 ~ p.154
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Antimicrobial Activity of Oleanolic Acid, Ursolic Acid, and Sophoraflavanone G against Periodontopathogens
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Kook Joong-Ki
Park Soon-Nang
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Abstract
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In general, oleanolic acid (OA) and ursolic acid (UA) haveantimicrobial effect against Gram-positive bacteria but notGram-negative bacteria whereas sophoraflavanone G hasantimicrobial activity against both bacterial types. However,the antimicrobial effects of OA, UA, and sophoraflavanone Gagainst periodontopathogens have not been studied to anygreat extent. The aim of this study was to investigateantimicrobial effect of OA, UA, and sophoraflavanone Gagainst 15 strains (5 species) of oral Gram-negative bacteria,which are the major causative bacteria of periodontal disease.The antimicrobial activity was evaluated by minimalinhibitory concentration (MIC) and minimum bactericidalconcentration (MBC) determinations. OA and UA showedantimicrobial effects against all of the Porphyromonasgingivalis strains tested and also Prevotella intermedia ATCC25611T. Interestingly, P. intermedia ATCC 49046 showedgreater resistance to OA and UA than P. intermedia ATCC25611T. In contrast, sophoraflavanone G had antimicrobialactivity against all strains, with MIC and MBC values below32 μg/ml, except Aggregatibacter actinomycetemcomitans.These results indicate that sophoraflavanone G may havepotential for use in future oral hygiene products such asdentifrices and gargling solution to prevent periodontitis.
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KEYWORD
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antimicrobial effect, oleanolic acid, periodontopathogens, sophoraflavanone G, ursolic acid
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